Atherosclerosis is a chronic, inflammatory disease of blood vessels, characterised by the build up of cholesterol-rich, inflamed lesions, called plaque. As plaques build up, they cause narrowing to arteries and restrict blood flow to organs and tissues. Sometimes plaques become disturbed and form clot which can lead to complete obstruction of the artery. This in turn causes tissue infarction, w...Learn More / Apply
Tuberculosis is now the deadliest bacterial disease affecting the world. Our research group uses the zebrafish model system to better understand and treat this disease. The zebrafish is an excellent model for the study of infectious diseases by live imaging.
Mycobacterial infection drives the formation of complex aggregates of immune cells known as granulomas, and these can be readily...Learn More / Apply
Infertility affects approximately 1 in 20 Australian men of reproductive age, with 40% of cases having an unknown cause; as such, few targeted treatments can be provided. While assisted reproductive technologies (ART) have greatly improved over the years, still only ~20% of ART treatments where the male factor is the problem result in a live birth; at ~$4000/cycle, this presents a significant b...Learn More / Apply
Increasing evidence suggests that patients with chronic inflammatory disease are at a higher risk of developing heart disease. Using a range of preclinical studies we will investigate the mechanistic pathways that link systemic inflammation and heart disease.Learn More / Apply
T cells modified to express tumour-directed chimeric antigen receptors (CAR) have shown clinical efficacy in early phase clinical trials. These trials have used patients’ own T-cells modified to express CARs targeting CD19 antigen found on most B-cell malignancies. This therapy however, is associated with a variety of problems, including often a limited persistence of adoptive...Learn More / Apply
White Dwarfs are the end points of the evolution of stars like the Sun. The numbers of such stars, their masses and their kinematics are capable of revealing information on subjects as diverse as stellar evolution and mass loss processes and the age of the Galaxy's disk. The northern hemisphere sky has been searched for white dwarfs using the Sloan Digital Sky Survey but a compl...Learn More / Apply